Biomedical

Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system that can deliver messenger RNA (mRNA) to the brain via intravenous injection – a challenge that has long been limited by the protective nature of the blood-brain barrier. The system takes advantage of natural transport mechanisms within the blood-brain barrier that move nanoparticles across the blood-brain barrier.

Researchers from Vanderbilt University have developed advanced dialysis membranes using an atomically thin material called graphene. These innovative membranes leverage a protein-enabled sealing mechanism that works as follows: When proteins escape through larger pores, they react with molecules on the other side of the graphene membrane. This reaction triggers a sealing process, selectively closing larger pores while preserving smaller ones. This self-sealing capability ensures precise size-selective filtration and improves the membrane's overall effectiveness.

A major challenge in self-powered wearable sensors for health care monitoring is distinguishing different signals when they occur at the same time. Now, researchers from Penn State and Hebei University of Technology in China have addressed this issue by developing a new type of flexible sensor that can accurately measure both temperature and physical strain simultaneously but separately, potentially enabling better wound healing monitoring.

Researchers from Georgia Tech, Emory University, and the University of California, Davis, have created a technique that could lead to new, less-invasive treatments for blood disorders and genetic diseases. "This would be an alternative to invasive hematopoietic stem cell therapies – we could just give you an IV drip," said James Dahlman, one of the researchers involved in this study.

Researchers from Columbia University; the Molecular Foundry at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory; and the University of Utah have invented new nanoscale sensors of force. They are luminescent nanocrystals that can change intensity and/or color when you push or pull on them. These "all-optical" nanosensors are probed with light only and therefore allow for fully remote read-outs—no wires or connections are needed.

Researchers from Carnegie Mellon University have found a way to control the size and structure of active colloids while yielding more than 100 times the amount created by earlier fabrication methods. The team's active colloids are linked together using DNA nanostructures – an innovation that makes them flexible, agile, and responsive to signals in their environment. Typically, DNA nanotechnology can only be studied using expensive equipment.

Most cancers occur when there is an imbalance of cellular growth and inhibition, causing cells to grow rapidly and form tumors in the body. In the case of prostate cancer, no therapies exist to simultaneously correct tumor growth and restore tumor suppression. To restore this balance, researchers from Brigham and Women's Hospital, which is part of Harvard Medical School, have used lipid nanoparticles to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) to human prostate cancer cells.

Researchers from Georgia Tech and the University of California Riverside have developed biosensors made of iron oxide nanoparticles and special molecules called cyclic peptides that recognize tumor cells better than current biosensors. The cyclic peptides respond only when they encounter two specific types of enzymes – one secreted by the immune system, the other by cancer cells. In animal studies, the biosensors distinguished between tumors that responded to a common cancer treatment that enhances the immune system from tumors that resisted treatment.

Researchers from the University of Pennsylvania; the Wistar Institute in Philadelphia, PA; Central South University in Changsha, China, have engineered small nano-sized capsules called extracellular vesicles from human cells to target a cell-surface receptor called DR5 (death receptor 5) that many tumor cells have. When activated, DR5 can trigger the death of these tumor cells by a self-destruct process called apoptosis. Researchers have been trying for more than 20 years to develop successful DR5-targeting cancer treatments.

A new experimental vaccine developed by researchers from the Massachusetts Institute of Technology, Massachusetts General Hospital, Caltech, and the University of Cambridge in the United Kingdom could offer protection against emerging variants of SARS-CoV-2, as well as related coronaviruses, known as sarbecoviruses, that could spill over from animals to humans. Sarbecoviruses include SARS-CoV-2 (the virus that causes COVID-19) and the virus that led to the outbreak of the original SARS in the early 2000s.