News from the NNI Community - Research Advances Funded by Agencies Participating in the NNI

Using a protein nanoparticle they designed, scientists at the University of Illinois Chicago have identified two distinct subtypes of neutrophils and found that one of the subtypes can be used as a drug target for inflammatory diseases. Neutrophils are a type of white blood cell that help fight infection, clear dead cell debris, and heal tissue injury. Further investigation with the nanoparticle showed that the subtypes have different cell surface receptors and that they are functionally distinct in their helpful capacities to kill bacteria and their harmful potential to promote inflammation. 

Scientists at the University of Illinois Chicago have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose – a type of sugar – to stop a population of lung cells called macrophages that contribute to lung tissue scarring. The cell-targeting method holds promise for preventing this severe lung scarring disease, which can result in life-threatening complications, such as shortness of breath.

Curcumin, a compound found in turmeric, has anti-inflammatory and antioxidant properties and is known to suppress the production of blood vessels in malignant tumors. Bioengineers at the University of California Riverside have now discovered that when delivered through magnetic hydrogels into stem cell cultures, curcumin paradoxically also promotes the secretion of vascular endothelial growth factor, which helps vascular tissues grow. (The hydrogel contained magnetic iron oxide nanoparticles that were coated with curcumin.)

Researchers from the University of California, Berkeley, the U.S. Department of Energy’s Lawrence Berkeley National Laboratory, and the National Institute for Materials Science in Tsukuba, Japan, have determined that interactions between electrons are what give rise to the divergent effects observed when graphene is doped with electrons versus holes. Electron–hole asymmetry in graphene has mainly been attributed to extrinsic sources such as impurities and strain, as opposed to intrinsic effects such as particle interactions. In this work, the researchers determined that, contrary to earlier thinking, intrinsic electronic correlations are, in fact, the primary driver of graphene’s electron–hole asymmetry.

An international team of scientists has shown that extremely small arrays of magnets can order themselves by increasing entropy, or the tendency of physical systems to disorder, a behavior that appears to contradict standard thermodynamics. The system examined in this work, called tetris spin ice, is composed of two-dimensional arrays of very small magnets that are “frustrated,” that is, they remain disordered, even though the system retains some order. 

Researchers from Texas A&M University have developed water-stable, 2D covalent organic framework (COF) nanoparticles that can direct the differentiation of human mesenchymal stem cells into bone cells. Until now, the difficulty of processing COFs into nanosized materials – along with their poor stability – has limited their application in regenerative medicine. The researchers state that to the best of their knowledge, this is the first report demonstrating the ability of COFs to direct stem cells toward bone tissue.

The Rice University laboratory of chemist James Tour has modified its flash Joule heating process to produce doped graphene that tailors its structures and electronic states to make them more suitable for optical and electronic nanodevices. The doping process adds other elements – a single element, pairs of elements, or trios of elements – to graphene’s 2D carbon matrix. The process takes about one second, is both catalyst- and solvent-free and is entirely dependent on “flashing” a powder that combines the dopant elements with carbon.

Researchers at the University of Illinois Urbana-Champaign have developed a new method to measure changes that occur in materials, such as glasses, at the nanoscale. The researchers extended an imaging technique used for scanning electron microscopes so it can also be used for transmission electron microscopes. The technique, called digital image correlation, takes a series of images and compares one image to the next in order to map what is happening in a material over time. 

Researchers from MIT, Columbia University, and the National Institute for Materials Science in Tsukuba, Japan, have engineered a new property into a well-known family of semiconductors, called transition metal dichalcogenides, by manipulating ultrathin sheets of the materials only a few atomic layers thick. The researchers showed that when two single sheets of a transition metal dichalcogenide are stacked parallel to each other, the material becomes ferroelectric. In a ferroelectric material, positive and negative charges spontaneously head to different sides. 

Researchers from the U.S. Department of Energy's Pacific Northwest National Laboratory and the University of Washington have successfully designed a bio-inspired molecule that can direct gold atoms to form perfect nanoscale stars. The work is a step toward understanding and controlling the shapes of metal nanoparticles and creating advanced materials with tunable properties