News from the NNI Community - Research Advances Funded by Agencies Participating in the NNI

Having already created a technology that makes bone scaffolds with collagen-like nanostructures, researchers from the University of Michigan have now regenerated bone by improving cell-matrix interactions. The latest discovery is especially beneficial for patients needing repairs involving larger amounts of bone. "What we invented are biodegradable polymer templates that contain peptides on nanofibers, acting like keys to open new gates to liberate the locked bone regeneration potential from the recipient's own cells," said Peter Ma, one of the scientists involved in this study.

Researchers at the University of Hawaiʻi at Manoa in Honolulu have unveiled a new technique that could make the manufacture of wearable health sensors more accessible and affordable. Producing these devices often requires specialized facilities and technical expertise, limiting their accessibility and widespread adoption. So, the researchers introduced a low-cost, stencil-based method for producing sensors made from laser-induced graphene, a key material used in wearable sensing. "This advancement allows us to create high-performance wearable sensors with greater precision and at a lower cost," said Tyler Ray, the researcher who led this study.

Cellulose nanocrystals derived from renewable resources have shown great potential for use in composites, biomedical materials, and packaging. But a major challenge in the production of cellulose nanocrystals is the energy-intensive drying process. To address this issue, a team of researchers from the University of Illinois Urbana-Champaign, Purdue University, and North Carolina Agricultural and Technical State University has introduced a novel multi-frequency ultrasonic drying technology. This method not only accelerates the drying process but also reduces energy consumption, compared to traditional drying techniques.

Supplies of nickel and cobalt, which are commonly used in the cathodes of lithium-ion batteries, are limited. Now, new research led by researchers from the U.S. Department of Energy's Lawrence Berkeley National Laboratory opens up a potential low-cost, safe alternative in manganese, the fifth most abundant metal in the Earth's crust. The researchers showed that manganese can be effectively used in emerging cathode materials called disordered rock salts. They used state-of-the-art electron microscopes to capture atomic-scale pictures of the manganese-based material in action and found that it formed a nanoscale semi-ordered structure that enhanced the battery performance.

Researchers from Texas A&M University have developed molybdenum disulfide nanoflowers that can stimulate mitochondrial regeneration, helping cells generate more energy. According to Akhilesh Gaharwar, one of the researchers involved in this study, the nanoflowers could offer new treatments for muscle dystrophy, diabetes, and neurodegenerative disorders by increasing ATP production, mitochondrial DNA, and cellular respiration. "This discovery is unique," said Vishal Gohil, another researcher involved in the study. "We are not just improving mitochondrial function; we are rethinking cellular energy entirely. The potential for regenerative medicine is incredibly exciting."

Researchers from Penn State, Purdue University, Intel Corporation (Santa Clara, CA), The Kurt J. Lesker Company (Jefferson Hills, PA), and National Yang Ming Chiao Tung University in Taiwan have developed a process to produce a "rust-resistant" coating with additional properties ideal for creating faster, more durable electronics. Traditional methods to protect two-dimensional (2D) semiconductor materials from rusting involve oxide-based coatings, but these processes often use water, which can accelerate the oxidation they aim to prevent. The team's approach was to use amorphous boron nitride as a coating material, which was evenly coated on the 2D materials by using a new two-step atomic layer deposition method.

Researchers from New York University have begun to explore exosomes, tiny membrane-bound vesicles, as promising tools for wound healing. These nanovesicles carry various biological materials – nucleic acids, proteins, and lipids – allowing them to mediate intercellular communication and influence processes such as tissue repair. By combining them with hydrogels, which are composed of networks of cross-linked polymers, the researchers showed that hydrogel-exosome combinations consistently lead to faster wound closure than either hydrogels or exosomes used alone.

Using a ventilator-on-a-chip developed at The Ohio State University, researchers have found that shear stress from the collapse and reopening of the air sacs is the most harmful type of damage. This miniature organ-on-a-chip model simulates lung injury during mechanical ventilation, said Samir Ghadiali, one of the scientists involved in this study. The ventilator-on-a chip’s measurement of real-time changes to cells was enabled by an innovative approach: growing human lung cells on a synthetic nanofiber membrane mimicking the complex lung matrix. This ventilator-on-a-chip is closer to the authentic ventilated lung microenvironment than any similar lung chip systems to date, the researchers said.

Researchers from the University of Texas at Dallas and Vanderbilt University have found that X-rays of the kidneys using gold nanoparticles as a contrast agent might be more accurate in detecting kidney disease than standard laboratory blood tests. Based on their study in mice, the researchers also realized that caution may be warranted in using renal-clearable nanomedicines to patients with compromised kidneys. For example, they found that in mice with severely injured kidneys, nanoparticle transport through the kidneys was slowed down significantly, a situation that caused the nanoparticles to stay in the kidneys longer.

A key step toward reusing carbon dioxide to make sustainable fuels is chaining carbon atoms together, and an artificial photosynthesis system developed at the University of Michigan can bind two of them into hydrocarbons. The system produces ethylene – a hydrocarbon typically used in plastics – with efficiency, yield, and longevity above other artificial photosynthesis systems. The device absorbs light through two kinds of semiconductors: a forest of gallium nitride nanowires, each just 50 nanometers wide, and the silicon base on which they were grown. The reaction transforming water and carbon dioxide into ethylene takes place on copper clusters that dot the nanowires.