Scientists from The Johns Hopkins University, the Mayo Clinic, and Tufts University have developed a potential new way to treat a variety of rare genetic diseases marked by too low levels of specific cellular proteins. To boost those proteins, the scientists created a genetic "tail" that attaches to messenger RNA (mRNA) molecules that churn out the proteins. To deliver these genetic tails, also called “mRNA boosters,” the scientists encased them in nanoparticles covered in lipids. The nanoparticles are naturally absorbed by cells through their fatty outer membranes. After the scientists administered the mRNA boosters to laboratory mice, each group of mice had 1.5 to two times more of the proteins specific to the mRNA boosters than control mice that did not receive the boosters.
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