News from the NNI Community - Research Advances Funded by Agencies Participating in the NNI

MIT scientists have built a system containing alternating semiconductor layers that could potentially protect quantum bits (qubits) from degrading into regular bits by realizing a phenomenon called many-body localization (MBL). Three-nm-thick alternating layers of aluminum arsenide and gallium arsenide were used to create a microscopic “lasagna” 600 layers deep, with "nanodots," 2-nm particles of erbium arsenide, dispersed between the layers. The identification of MBL signatures provides new opportunities to study quantum phenomena, and potential applications range from thermal storage to quantum computing.

Engineers at Texas A&M University have designed a 3D-bioprinted model of a blood vessel that mimics its state of health and disease. Current bioinks used to print blood vessels in 3D are unable to deposit a high density of living cells into complex 3D architectures, making them less effective. To overcome these shortcomings, the engineers developed a new nanoengineered bioink to print 3D, anatomically accurate, multicellular blood vessels. Their approach offers improved real-time resolution for both macro-structure and tissue-level micro-structure, which is currently not possible with available bioinks.

An interdisciplinary team of researchers from the University of North Carolina at Charlotte, North Carolina State University, Columbia University, and Frederick National Laboratory for Cancer Research utilized DNA for the precise assembly of quantum dots into larger three-dimensional scaffolds. The unique optical properties of these semiconductor nanoparticles have been previously utilized in several applications, including for imaging and biosensing. 

Scientists from Rice University and Tokyo Metropolitan University have woven custom-made #nanotube fibers into enhanced, flexible #cotton #fabric that turns #heat into enough #energy to power a light-emitting diode (#LED). The researchers note that the nanotube-enhanced materials could become building blocks for fiber and #textile #electronics and energy harvesting. The materials can act as both #thermoelectric generators and heat sinks to actively cool sensitive electronics with high efficiency.

Immunotherapies help boost the immune system's ability to fight off cancer cells. Immune checkpoints are regulators of the immune system, but some types of cancer circumvent these checkpoints, allowing cancerous cells to avoid detection and continue to spread. Immune checkpoint blockade (ICB) is a newer therapy that can essentially "release the brakes" on the immune system and help the body fight back. Researchers at the University of Arizona Health Sciences have created the first nanotherapeutic platform of its kind to enhance the ability of camptothecin, a chemotherapeutic agent, to synergize with ICB therapies, making them more effective against aggressive tumors.

Researchers from the U.S. Department of Energy's Brookhaven National Laboratory have developed an innovative technique for creating nanomaterials. The new electron beam nanofabrication technique, plasmon engineering, achieves unprecedented near-atomic scale control of patterning in silicon. Structures built using this approach produce record-high tuning of electro-optical properties. 

A UC Berkeley-led team found that using nanometer-thin layers of black phosphorus in optoelectronic devices and subjecting them to varying degrees of strain results in reversibly tunable output wavelengths over an unexpectedly large range. The ability to use a broader range of the infrared spectrum, tunable within one device, could help meet the growing demand for applications in optical communications, thermal imaging, health monitoring, spectroscopy, and chemical sensing. 

MIT engineers and colleagues report important new advances on a tunable metasurface, or flat optical device patterned with nanoscale structures, that they compare to a Swiss army knife while its passive predecessor can be thought of as just one tool, like a flat-bladed screwdriver. The new material, composed of germanium, selenium, antimony, and tellurium (GSST), is key to the new metasurface. The metasurface is a film of GSST only about half a millimeter square patterned with some 100,000 nanoscale structures which allow for control over the propagation of light. 

A biochemistry researcher from the University of Miami Miller School of Medicine has found that a nanoparticle drug delivery system can reduce HIV/AIDS viral reservoirs in the brain that normally contribute to neurological problems. Nanoparticle drug delivery offers a new strategy for treating HIV-associated neurocognitive disorders, such as HIV dementia, which can be magnified by recreational drug use in HIV-positive individuals.

Researchers from the University of Connecticut are collaborating to develop novel asthma therapeutics using gene-silencing nanocapsules in a bid to help patients who aren't benefiting from existing treatments. The nucleic acid nanocapsule is designed to selectively deliver an enzyme to silence a component of the immune response that leads to the over-expression of immune components that play a significant role in allergic asthma attacks.