News from the NNI Community - Research Advances Funded by Agencies Participating in the NNI

Date Published
(Funded in part by the U.S. Department of Energy and the National Science Foundation)

Researchers from the U.S. Department of Energy’s Berkeley Lab, the University of Central Florida, and Penn State have unveiled a new, fast, and readily reproducible way to map and identify defects in two-dimensional (2D) materials. It uses an application of artificial intelligence to quickly analyze data from autonomous experiments, which in recent years have become a powerful tool for imaging 2D materials.

(Funded by the National Institute of Standards and Technology)

The focused ion beam is an essential tool for cutting patterns as small as several billionths of a meter deep and wide in tiny industrial parts. But the focused ion beam has been limited by a trade-off between high speed and fine resolution. Now researchers at the National Institute of Standards and Technology have discovered that a masking process can virtually eliminate this trade-off, enabling a focused ion beam to machine at high current (and therefore high speed) without sacrificing fine resolution.

(Funded in part by the National Institutes of Health, the National Science Foundation, and the U.S. Department of Defense)

Using a suspended nanowire, researchers from the University of Massachusetts, Amherst, and the University of Missouri have, for the first time, created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. With its size much smaller than a single cell, the nanowire can tightly patch onto a cell’s membrane and "listen to" cellular activities. Also, it can convert "heard" bioelectrical and biomechanical activities into electrical sensing signals for detection.

(Funded by the National Science Foundation)

Researchers at the University of Illinois at Urbana-Champaign and Korea University in Seoul have devised a transparent infrared reflective coating. Designed with a nano-mesh structure, the coating transmits sunlight and reflects body thermal radiation. This new coating could be used in clothes that keep people warm in winter and in counter-surveillance military applications – specifically, to provide camouflage under the scrutiny of thermal imaging cameras. 

(Funded by the National Institutes of Health)

Scientists from Johns Hopkins University and the University of Washington have created a platform that shows promise in speeding up the design of lipid nanoparticles, which can be used to carry messenger RNA to cells and generate immunity. But the potency of mRNA begins to decline within 24 hours of its delivery. So, the scientists designed lipid nanoparticles that carry a promising alternative, called plasmid DNA, which can last for up to seven days. The researchers are now leveraging these nanoparticles to develop a vaccine against malaria. 

(Funded in part by the U.S. Department of Defense)

Researchers at Washington University in St. Louis have shown that when materials with nanopores are submerged in a highly saline liquid, the pH inside the nanopores can be as much as 100 times more acidic than in the bulk solution. The researchers developed plasmonic nanoparticle sensors that reported how pH changed as they moved through the pores and their immediate environment. Each sensor consists of a gold nanoparticle paired with a molecule that is sensitive to pH. 

(Funded by the U.S. Department of Veterans Affairs and the National Institutes of Health)

Researchers from Washington University School of Medicine and the University of South Florida Health Heart Institute have shown that an experimental nanoparticle-based drug therapy protects mice from sudden death due to the rupture of a major blood vessel in the abdomen, pointing the way toward a new strategy for treating deadly abdominal aortic aneurysms. The researchers used nanoparticles to deliver anti-inflammatory payloads directly to inflamed blood vessels. 

(Funded by the U.S. Department of Defense, the National Science Foundation, and the U.S. Department of Energy)

Researchers at The University of Texas at Austin and the U.S. Department of Energy’s Sandia National Laboratories have developed synaptic transistors for brain-like computers using the thin, flexible material graphene. These transistors are similar to synapses in the brain, which connect neurons to each other, and they can interact with living cells and tissue.

(Funded by the National Institutes of Health)

Researchers from Columbia University and Rover Diagnostics have built a platform that detects genetic material from viruses, gives results in 23 minutes, and matches laboratory-based tests. The platform leverages plasmonic nanoparticles – discrete metallic particles that respond to infrared light by releasing heat – and can be adapted to test for COVID-19, the flu, strep, and other viruses that require fast diagnosis.

(Funded in part by the National Institutes of Health and the National Science Foundation)

Researchers from Penn State, Hebei University of Technology, Tianjin Medical University General Hospital, and Beihang University have developed a new water-resistant gas sensor that can accurately and continuously monitor nitrogen dioxide and other gases in humid environments. The sensor detects nitrogen dioxide in breath, the concentration of which may indicate potential pulmonary diseases. The researchers used laser-induced graphene, a speedy, cost-effective, environmentally friendly fabrication method that uses laser writing to assemble two-dimensional graphene layers.