A team of engineers and neuroscientists from the University of California San Diego, the Salk Institute for Biological Studies, Boston University, and Oslo University Hospital in Norway has demonstrated, for the first time, that human brain organoids implanted in mice have established functional connectivity to the animals’ cortex and responded to external sensory stimuli. The implanted organoids reacted to visual stimuli in the same way as surrounding tissues, an observation that researchers were able to make in real time over several months thanks to an innovative experimental setup that combines transparent graphene microelectrode arrays and two-photon imaging.
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