(Funded by the U.S. Department of Energy and the U.S. Department of Defense)
Researchers from New York University and Charles University in Prague, Czech Republic, have observed growth-induced self-organized stacking domains when three graphene layers are stacked and twisted with precision. The findings demonstrate how specific stacking arrangements in three-layer graphene systems emerge naturally – eliminating the need for complex, non-scalable techniques traditionally used in graphene twisting fabrication. The size and shape of these stacking domains are influenced by the interplay of strain and the geometry of the three-layer graphene regions. Some domains form as stripe-like structures, tens of nanometers wide and extending over microns.

(Funded by the U.S. National Science Foundation and the National Institutes of Health)
Researchers at the University of Kentucky and the New York Blood Center in New York City have discovered that combining magnetic nanoparticles with ascorbic acid destroyed breast cancer cells, but only if the nanoparticles were added and went inside the cells first before the ascorbic acid was added. “This discovery underscores the significance of coordinating nanoparticles and ascorbic acid in cancer treatment,” said Sheng Tong, the scientist who led this study. The researchers also engineered a specific type of immune cell, called macrophages, to carry the nanoparticles to the tumor site. When loaded with magnetic nanoparticles, the macrophages can be guided to the tumor using an external magnetic field.

(Funded by the U.S. Department of Energy and the U.S. National Science Foundation)
Materials that conduct electricity well, like metals, also tend to conduct heat. But researchers at Drexel University, Villanova University, Temple University, Bryn Mawr College, Rice University, and Université catholique de Louvain in Belgium have discovered that MXenes, a type of material known for its excellent electrical conductivity, actually have very low thermal conductivity. This discovery challenges the usual link between electrical and heat conduction and could lead to new developments in building materials, performance apparel, and energy storage solutions. “Thermal insulation of this magnitude … would simply have been unimaginable until now,” said Yury Gogotsi, one of the scientists involved in this research. “This could change the way we insulate buildings and industrial equipment, and make thermal clothing, just to name a few exciting possibilities.”

(Funded by the U.S. Department of Energy, the U.S. National Science Foundation, and the National Institutes of Health)
Researchers at Southern Methodist University, the University of Texas at Arlington, the U.S. Department of Energy’s Brookhaven National Laboratory, and the Korea Institute of Science and Technology in Seoul have discovered a way to enhance the sensitivity of nanopores for early detection of diseases. They integrated octahedral DNA origami structures with solid-state nanopores to significantly improve the detection of proteins, especially those that are present in low concentrations. Nanopores are tiny holes that can detect individual molecules as they pass through. The researchers determined that combining the precision of DNA origami with the robustness of solid-state nanopores could create a “hybrid nanopore” system, enabling more precise analysis.

(Funded by the National Science Foundation, the U.S. Department of Defense, and the National Institutes of Health)
Researchers at the University of California San Diego have developed a platform for studying how nanoscale growing surfaces can impact cellular behavior. While previous studies have shown how surface structures can change cellular shape, little is known about their specific effects on cell metabolism. The research team found that cells grown on engineered nanopillar surfaces show dramatically different metabolic profiles than cells not grown on such surfaces. Also, the researchers found that growing cells on different engineered nanopillar surfaces could change how cells produce and modify lipids, the primary components of cell membranes.

(Funded by the National Science Foundation)
Researchers from North Carolina State University and Iowa State University have demonstrated a new technique for self-assembling electronic devices. The proof-of-concept work was used to create nanoscale and microscale diodes and transistors, and paves the way for self-assembling more complex electronic devices without relying on existing computer chip manufacturing techniques. The self-assembling technique follows a multistep process that makes use of liquid metal particles and a solution that contains molecules called ligands that are made up of carbon and oxygen. At some point during this process, the metal ions interact with the oxygen to form semiconductor metal oxides, while the carbon atoms form graphene sheets. These ingredients assemble themselves into a well-ordered structure consisting of semiconductor metal oxide molecules wrapped in graphene sheets.

(Funded by the U.S. Department of Defense and the National Science Foundation)
Scientists from the University of California, Berkeley; the University of California, Santa Cruz; Harvard University; the University of Manchester in the United Kingdom; and the National Institute for Materials Science in Tsukuba, Japan, have conducted an experiment that confirms a theory first put forth 40 years ago stating that electrons confined in quantum space would move along common paths rather than producing a chaotic jumble of trajectories. To conduct this experiment, the scientists combined advanced imaging techniques and precise control over electron behavior within graphene, a two-dimensional material made of carbon atoms. The scientists used the finely tipped probe of a scanning tunneling microscope to first create a trap for electrons and then hover close to a graphene surface to detect electron movements without physically disturbing them.

(Funded by the U.S. Department of Energy, the National Institutes of Health, and the National Science Foundation)
Researchers from the University of North Carolina Charlotte and the U.S. Department of Energy’s Brookhaven National Laboratory have developed an innovative computational framework for modeling multifunctional RNA nucleic acid nanoparticles. By integrating small and wide-angle x-ray scattering data with data-driven molecular dynamics simulations, the researchers developed a methodology for studying multistranded RNA nucleic acid nanoparticles in their solution-state environments. Small-angle x-ray scattering–Molecular Dynamics (SAXS–MD) guides simulations toward biologically meaningful conformations, addressing the limitations of traditional unconstrained molecular dynamics simulations.

(Funded by the National Institutes of Health)
Researchers at Rice University have developed an innovative imaging platform that promises to improve our understanding of cellular structures at the nanoscale. This platform offers significant advancements in super-resolution microscopy, enabling fast and precise three-dimensional (3D) imaging of multiple cellular structures. By integrating an angled light sheet, a nanoprinted microfluidic system, and advanced computational tools, the platform significantly improves imaging precision and speed, allowing for clearer visualization of how different cellular structures interact at the nanoscale.

(Funded by the U.S. Department of Energy)
Scientists from Clark Atlanta University and the Molecular Foundry at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory have discovered a faster, more sustainable method for making metal-encapsulated covalent organic frameworks – materials that have the potential to play a crucial role in catalysis, energy storage, and chemical sensing. The new one-step, room-temperature process eliminates the need for toxic solvents and significantly reduces the production time from several days to just one hour. The covalent organic frameworks were evaluated to see how porous and crystalline they are and how much metal was added to the structure. Also, powerful transmission electron microscopes were used to visualize the covalent organic framework structure and the distribution of metal throughout.