(Funded by the National Institutes of Health)
Scientists from the University of Michigan and the University of Virginia have shown that nanoparticles delivered intravenously in mice can block allergic reactions to red meat caused by the bite of the lone star tick. The nanoparticles contain allergens that re-train the immune system to ignore the type of sugar found in beef, pork, and lamb. Once the nanoparticles were delivered to the mice, the scientists exposed these mice to ticks to trigger an immune response. In 10 out of 12 mice, a reduced immune response was recorded.

(Funded by the National Institutes of Health)
Researchers from Johns Hopkins University, the University of Texas Southwestern Medical Center, St. Jude Children’s Research Hospital, and Harvard University have developed nanoparticles that can send gene treatment directly to various types of cells in bone marrow to correct mutations that cause sickle cell disease. The researchers used CRISPR/Cas and base gene-editing techniques in a mouse model of sickle cell disease to activate a form of hemoglobin and correct the sickle cell mutation.

(Funded by the U.S. Department of Defense and the National Institutes of Health)
Engineers at Johns Hopkins University have created a new optical tool that could improve cancer imaging. Their approach uses tiny nanoprobes that light up when they attach to aggressive cancer cells, helping clinicians distinguish between localized cancers and those that are metastatic and have the potential to spread throughout the body. The team found that unlike CT or MRI scans, the nanoprobes effectively and consistently bound to metastatic prostate cancer cells and differentiated between them and non-metastatic cells.

(Funded by the National Institutes of Health and the National Science Foundation)
Researchers from Vanderbilt University, Yale University, Northwestern University, and AstraZeneca have developed a set of nanoparticles that stimulate the immune system in mice to fight cancer and may eventually do the same in humans. The nanoparticles delivered a nucleic acid molecule that triggers an immune response that is normally used by the body to recognize foreign viruses to help the immune system mount a defense, according to the researchers.

(Funded by the National Institutes of Health)
Researchers from Rice University and the University of Texas MD Anderson Cancer Center have developed ultrasmall, stable gas-filled protein nanostructures that could revolutionize ultrasound imaging and drug delivery. These diamond-shaped, 50-nanometer gas vesicles are believed to be the smallest stable, free-floating structures for medical imaging ever created. They can penetrate tissue and reach immune cells in lymph nodes. This discovery opens up new possibilities for imaging and delivering therapies to previously inaccessible cells. “The research has notable implications for treating cancers and infectious diseases, as lymph-node-resident cells are critical targets for immunotherapies,” said George Lu, one of the researchers involved in this study.