Nanoparticle researchers develop microfluidic platform for better delivery of gene therapy for lung disease

Researchers from Oregon State University and Funai Microfluidic Systems (Lexington, KY) have developed a novel technique for the aerosolization of inhalable nanoparticles that can be used to carry messenger RNA (mRNA) to the lungs of patients with inherited lung diseases. The findings are important because the current nebulization method for nanoparticles subjects them to shear stress, hindering their ability to encapsulate the genetic material and causing them to aggregate in certain areas of the lungs rather than spread out evenly, the researchers said. "We utilized a novel microfluidic chip that helps in generation of plumes that carry nanoparticles and does not cause any shear stress," said Gaurav Sahay, a scientist who led this study. "This device is based on the similar idea of an ink-jet cartridge that generates plumes to print words on paper."