MSU Researchers Set New Standards for Nanoparticles and Show How a New Treatment Helps Patients With MS, ALS, Parkinson’s Disease

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(Funded by the National Institutes of Health and the National Science Foundation)

By analyzing the protein corona composition of gold nanoparticles, researchers from Michigan State University; the University of South Florida; Postnova Analytics Inc. in Salt Lake City, UT; and Clene Nanomedicine Inc. in Salt Lake City, UT, have explained how the protein corona helps to treat neurodegenerative diseases. The nanoparticles pass through the gastrointestinal tract and enter the body's circulatory system, where they interact with, and become coated by, blood proteins and other biomolecules. This forms the protein corona. "Our research shows that these gold nanocrystals, manufactured using a novel method to form specific structures and without surfactants, can form a distinct protein corona that facilitates access to brain tissue," says Morteza Mahmoudi, one of the scientists involved in this study.

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