A Moonshot for Obesity: New Molecules, Inspired by Space Shuttles, Advance Lipid Nanoparticle Delivery for Weight Control

Researchers at the University of Pennsylvania and Case Western Reserve University have developed an in situ method for rapid and efficient synthesis of degradable branched lipidoids, key components of lipid nanoparticles, which are used for delivery of messenger RNA (mRNA) vaccines. The new method simplifies the manufacture of lipid nanoparticles and improves their ability to deliver mRNA to cells. The team tested the method for the treatment of obesity and genetic diseases.