An official website of the United States government.
Date posted
Funding Agency
(Funded by the National Institutes of Health)
Combining their expertise in protein engineering and synthetic DNA technology, scientists at the Wistar Institute in Philadelphia have successfully delivered nanoparticle antitumor vaccines that stimulated robust T cell immunity and controlled melanoma growth in preclinical models. The vaccines, which displayed 60 copies of protein parts derived from melanoma-specific antigens, were tested in mouse models of melanoma and resulted in prolonged survival that depended on T cell activation.
