DNA nanoswitches respond to RNA degrading enzymes, with applications in biosensing and molecular computing

A team of researchers from the University at Albany, State University of New York has developed DNA nanoswitches that can detect the presence of ribonucleases, which are enzymes that degrade RNA. The team used structure-changing DNA nanoswitches that turn from "signal on" to "signal off" in the presence of ribonucleases, giving a direct readout using the common lab method of gel electrophoresis. In the study, the researchers were able to detect low levels of ribonuclease H and used the detection to screen enzyme inhibitors that are considered drug candidates for HIV.