Protecting DNA Origami for Anti-Cancer Drug Delivery

Date posted
Funding Agency
(Funded by the U.S. Department of Energy)

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have designed and synthesized chains of molecules with a precise sequence and length to efficiently protect 3-D DNA nanostructures from structural degradation under a variety of biomedically relevant conditions. They demonstrated how these "peptoid-coated DNA origami" have the potential to be used for delivering anti-cancer drugs and proteins, imaging biological molecules, and targeting cell-surface receptors implicated in cancer.