Date posted
Funding Agency
(Funded by the National Institutes of Health and the National Science Foundation)
Researchers at Johns Hopkins University School of Medicine have demonstrated that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. The researchers found that a combination of the suicide gene and ganciclovir delivered by intraperitoneal injection to mice killed more than 65% of two types of pediatric brain tumor cells.