The Agriculture and Food Research Initiative (AFRI) is America’s flagship competitive grants program that provides funding for fundamental and applied research, education, and extension projects in the food and agricultural sciences. In this RFA, NIFA requests applications for six AFRI priority areas through the Foundational and Applied Science Program for FY 2020. Applicants considering applying to the second year should check the AFRI RFA webpage and www.grants.gov. The goal of this program is to invest in agricultural production research, education, and extension projects for more sustainable, productive and economically viable plant and animal production systems. The global agricultural output needs to be expanded significantly to meet the food needs of the population expected in 2050; thus, it is imperative to develop innovative, safe and sustainable management strategies for livestock, crops, and critical underlying resources.