Silencing RNA nanotherapy shows promise against pancreatic cancer

Date posted
Funding Agency
(Funded by the National Institutes of Health)

Scientists from Washington University School of Medicine in St. Louis and the University of South Florida Health Morsani College of Medicine, Tampa, Fla., have demonstrated that peptide-based nanoparticles can suppress pancreatic cancer growth without the toxic side effects and therapeutic resistance seen in drug trials. The nanoparticles deliver an RNA molecule that silences the chemical signal telling a gene to make mutated proteins that cause pancreatic cells to grow uncontrollably and resist existing cancer-killing drugs.