(Funded by the U.S. Department of Defense and the National Science Foundation)
Researchers from Harvard University and the University of Castilla-La Mancha in Spain have been able to successfully put tadpoles into a hibernation-like torpor state using donepezil, a drug approved by the U.S. Food and Drug Administration to treat Alzheimer’s. This advance means that donepezil could potentially be repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital. When used on its own, the drug seemed to cause some toxicity in the tadpoles, so the researchers encapsulated donepezil inside lipid nanocarriers, which reduced toxicity and caused the drug to accumulate in the tadpoles’ brain tissue – a promising result, because the central nervous system is known to mediate hibernation and torpor in animals.

(Funded by the U.S. Department of Defense and the National Science Foundation)
Just a few years ago, researchers discovered that changing the angle between two layers of graphene, an atom-thick sheet of carbon, also changed the material’s electronic and optical properties. To study the physics underlying this phenomenon, researchers usually produce tens to hundreds of different configurations of the twisted graphene structures – a costly and labor-intensive process. Now, researchers from the Massachusetts Institute of Technology, Harvard University, Stanford University, the University of California, Berkeley, and the National Institute for Materials Science in Tsukuba, Japan, have created a device that can twist a single structure in countless ways. In other words, the researchers demonstrated the world’s first micromachine that can twist two-dimensional (2D) materials at will.

(Funded by the National Institutes of Health and the National Science Foundation)
Engineers at the University of Virginia have created a drug nanocarrier designed to cure chronic or deadly respiratory diseases by slipping past the lungs’ natural defenses. The engineers successfully demonstrated the nanocarrier’s effectiveness using a device that captures the geometric and biological features of human airways. “We think this innovation not only promises better treatments of lung diseases with reduced side effects, but also opens possibilities for treating conditions affecting mucosal surfaces throughout the body,” said Liheng Cai, one of the engineers involved in this study.

(Funded by the National Science Foundation)
Researchers from the University of Michigan and Indiana University have shown that by combining an electron microscope, a small sample holder with microscopic channels, and computer simulations, it is possible to see how nanoscale building blocks can rearrange into different organized structures. In the study, the researchers suspended nanoparticles in tiny channels of liquid on a microfluidic flow cell. The researchers learned that the instrument gave the nanoparticles – which normally are attracted to each other – just enough electrostatic repulsion to push them apart and allow them to assemble into ordered arrangements.

This article features Heman Bekele, a high school student who was named “Kid of the Year 2024” by TIME magazine. Bekele is working on a soap that that could one day treat, and even prevent, multiple forms of skin cancer. His idea is to combine the soap with a lipid-based nanoparticle that would linger on the skin when the soap is washed away. The article is accompanied by a short video interview with Bekele.

(Funded by the U.S. Department of Defense)
Researchers from the University of Maryland, the University of Maryland, the University of California, Los Angeles, and the National Institute of Standards and Technology have envisioned a modular system for scaling quantum processors with a flexible way of linking qubits over long distances. While there are many types of qubits, the researchers chose to study quantum dot-based spin qubits that interact through microwave photons in a superconducting cavity. (Quantum dots are semiconductor nanoparticles that have unique size- and shape-dependent optoelectronic properties.) The researchers provided comprehensive guidelines for tailored long-distance entangling links by making multiple frequencies available for each qubit to become linked with microwave cavity photons of a given frequency.

(Funded by the National Science Foundation)
University of California, Irvine scientists have discovered a one-dimensional nanoscale material whose color changes as temperature changes. “We found that we can make really small and sensitive thermometers,” said Maxx Arguilla, one of the scientists involved in this study. Arguilla likened the thermometers to “nano-scale mood rings,” referring to the jewelry that changes color depending on the wearer’s body temperature. But instead of simply taking a qualitative temperature reading, the changes in the color of these materials “can be calibrated and used to optically take temperature readings at the nanoscale,” Arguilla said.

(Funded by the National Institutes of Health)
Scientists from the University of Michigan and the University of Virginia have shown that nanoparticles delivered intravenously in mice can block allergic reactions to red meat caused by the bite of the lone star tick. The nanoparticles contain allergens that re-train the immune system to ignore the type of sugar found in beef, pork, and lamb. Once the nanoparticles were delivered to the mice, the scientists exposed these mice to ticks to trigger an immune response. In 10 out of 12 mice, a reduced immune response was recorded.

(Funded by the U.S. Department of Defense, the U.S. Department of Energy, and the National Science Foundation)
Physicists from Purdue University, Washington University in St. Louis, and the U.S. Department of Energy’s Sandia National Laboratories have levitated a fluorescent nanodiamond and spun it at incredibly high speeds (up to 1.2 billion times per minute). The fluorescent diamond emitted and scattered multicolor lights in different directions as it rotated. When illuminated by a green laser, the nanodiamond emitted red light, which was used to read out its electron spin states. An additional infrared laser was shone at the levitated nanodiamond to monitor its rotation. Like a disco ball, as the nanodiamond rotated, the direction of the scattered infrared light changed, carrying the rotation information of the nanodiamond.

(Funded by the U.S. Department of Energy and the U.S. Department of Defense)
Scientists from Yale University and the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory (BNL) have developed a systematic approach to understanding how energy is lost from the materials that make up qubits. Energy loss inhibits the performance of these quantum computer building blocks, so determining its sources can help bring researchers closer to designing quantum computers. To conduct this work, the scientists used electron microscopes from the Center for Functional Nanomaterials, a DOE-funded user facility at BNL.