(Funded by the U.S. Department of Energy)
Researchers from North Carolina State University and Johns Hopkins University have demonstrated a technology that uses DNA to store data. The new technology is made possible by recent techniques that have enabled the creation of soft polymer materials that have unique morphologies. “Specifically, we have created polymer structures that we call dendricolloids – they start at the microscale, but branch off from each other in a hierarchical way to create a network of nanoscale fibers,” says Orlin Velev, one of the researchers involved in this study. “The ability to distinguish DNA information from the nanofibers it’s stored on allows us to perform many of the same functions you can do with electronic devices,” says Kevin Lin, another researcher involved in this study.

(Funded by the U.S. Department of Defense and the National Science Foundation)
Researchers from Harvard University and the University of Castilla-La Mancha in Spain have been able to successfully put tadpoles into a hibernation-like torpor state using donepezil, a drug approved by the U.S. Food and Drug Administration to treat Alzheimer’s. This advance means that donepezil could potentially be repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital. When used on its own, the drug seemed to cause some toxicity in the tadpoles, so the researchers encapsulated donepezil inside lipid nanocarriers, which reduced toxicity and caused the drug to accumulate in the tadpoles’ brain tissue – a promising result, because the central nervous system is known to mediate hibernation and torpor in animals.

(Funded by the U.S. Department of Defense and the National Science Foundation)
Just a few years ago, researchers discovered that changing the angle between two layers of graphene, an atom-thick sheet of carbon, also changed the material’s electronic and optical properties. To study the physics underlying this phenomenon, researchers usually produce tens to hundreds of different configurations of the twisted graphene structures – a costly and labor-intensive process. Now, researchers from the Massachusetts Institute of Technology, Harvard University, Stanford University, the University of California, Berkeley, and the National Institute for Materials Science in Tsukuba, Japan, have created a device that can twist a single structure in countless ways. In other words, the researchers demonstrated the world’s first micromachine that can twist two-dimensional (2D) materials at will.

(Funded by the National Institutes of Health and the National Science Foundation)
Engineers at the University of Virginia have created a drug nanocarrier designed to cure chronic or deadly respiratory diseases by slipping past the lungs’ natural defenses. The engineers successfully demonstrated the nanocarrier’s effectiveness using a device that captures the geometric and biological features of human airways. “We think this innovation not only promises better treatments of lung diseases with reduced side effects, but also opens possibilities for treating conditions affecting mucosal surfaces throughout the body,” said Liheng Cai, one of the engineers involved in this study.

(Funded by the National Science Foundation)
Researchers from the University of Michigan and Indiana University have shown that by combining an electron microscope, a small sample holder with microscopic channels, and computer simulations, it is possible to see how nanoscale building blocks can rearrange into different organized structures. In the study, the researchers suspended nanoparticles in tiny channels of liquid on a microfluidic flow cell. The researchers learned that the instrument gave the nanoparticles – which normally are attracted to each other – just enough electrostatic repulsion to push them apart and allow them to assemble into ordered arrangements.