(Funded by the National Institutes of Health)
A nanoparticle vaccine designed to fight cancers induced by human papillomavirus (HPV) eradicated tumors in an animal model of late-stage metastatic disease. The findings could ultimately lead to a new type of vaccine that would be used to treat a variety of cancers. To develop a therapeutic vaccine against HPV-related cancers, researchers combined a polymer and a small-molecule drug that both activate stimulator of interferon genes (STING) – a protein that triggers immune activity – with a protein antigen called E7 derived from HPV. Together, these components formed nanoparticles about 25-30 nanometers in diameter (for comparison, 1 million nanometers equal 1 millimeter).

(Funded by the National Institute of Standards and Technology)
Scientists at the National Institute of Standards and Technology have developed a new technique for measuring how radiation damages DNA molecules. This technique, which passes DNA through tiny openings called nanopores, detects radiation damage faster and more accurately than existing methods. The technique could track how well a tumor is responding to radiation, allowing for personalized adjustments to treatment. Also, in nuclear accidents or radiation poisoning, traditional methods to assess radiation exposure may take days, but with this new technology, first responders can obtain real-time data in minutes.

(Funded by the U.S. Department of Energy)
Researchers at the U.S. Department of Energy’s Lawrence Livermore National Laboratory have developed a new type of electrically controlled, near-infrared smart window that can cut near-infrared light transmission by almost 50%. In these smart windows, carbon nanotubes are grown so they stand upright on the glass, like a microscopic forest. Depending on the voltage applied, the nanotubes can either absorb infrared light and block heat from the sun or let the infrared light through. Once the carbon nanotubes are put into either a blocking or transparent state, they retain charge well, and so, a continuous voltage is not needed to maintain that state. This property offers very low-power operation, a necessity to drive energy savings for the end user.

(Funded by the National Institute of Standards and Technology)
Researchers at the National Institute of Standards and Technology have demonstrated a new and faster method for detecting and measuring the radioactivity of minuscule amounts of radioactive material. The innovative technique, known as cryogenic decay energy spectrometry, could have far-reaching impacts, from improving cancer treatments to ensuring the safety of nuclear waste cleanup. The researchers use a specialized inkjet device to carefully dispense tiny amounts, less than 1 millionth of a gram, of a radioactive solution onto thin gold foils. These gold foils have a surface dotted with tiny pores just billionths of a meter in size. These nanopores help to absorb the tiny droplets of the radioactive solution. By precisely measuring the mass of the solution that is dispensed using the inkjet and then measuring the radioactivity of the dried sample on the gold foils, the researchers can calculate the radioactivity per unit mass of the sample.

(Funded by the U.S. National Science Foundation and the U.S. Department of Defense)
Researchers at Penn Engineering have made a surprising discovery: a new type of material that can pull water from the air and release it onto surfaces without any need for external energy. Originally stumbled upon by accident during unrelated experiments, the material combines water-attracting and water-repelling components at the nanoscale in a way that allows it to both capture moisture and push it out as visible droplets. This discovery could lead to new ways of collecting water in dry areas or cooling buildings and electronics using only evaporation without the need for any external energy.