(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers from Georgia Tech, Emory University, and the University of California, Davis, have created a technique that could lead to new, less-invasive treatments for blood disorders and genetic diseases. “This would be an alternative to invasive hematopoietic stem cell therapies – we could just give you an IV drip,” said James Dahlman, one of the researchers involved in this study. “It simplifies the process and reduces the risks to patients.” The procedure uses lipid nanoparticles that carry genetic instructions to hematopoietic stem cells, but unlike current therapies, in this procedure, the nanoparticles don’t have targeting ligands, and they can dodge the liver, which acts as the body’s primary blood filter.

(Funded by the U.S. Department of Defense)
Engineers from the Massachusetts Institute of Technology; The University of Texas at Dallas; Sungkyunkwan University in Suwon-si, South Korea; and the Samsung Advanced Institute of Technology in Suwon, South Korea, have created a multilayered chip design that doesn’t require any silicon wafer substrates and works at temperatures low enough to preserve the underlying layer’s circuitry. The multilayered chip consists of alternating layers of two different transition metal dichalcogenides (a type of 2D material): molybdenum disulfide, a promising material candidate for fabricating n-type transistors; and tungsten diselenide, a material that has potential for being made into p-type transistors. Both p- and n-type transistors are the electronic building blocks for carrying out any logic operation. The method will double the density of a chip’s semiconducting elements, particularly metal-oxide semiconductor (CMOS), which is a basic building block of a modern logic circuitry.

(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Engineers at the University of Pennsylvania have modified lipid nanoparticles to not only cross the blood-brain barrier but also to target specific types of cells, including neurons. The researchers showed how short strings of amino acids can serve as precise targeting molecules, enabling the lipid nanoparticles to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.

(Funded by the U.S. Department of Energy)
Researchers from the University of Missouri and the U.S. Department of Energy’s Oak Ridge National Laboratory have discovered a new type of quasiparticle that is found in nanostructured magnets, no matter their strength or temperature. “We’ve all seen the bubbles that form in sparkling water or other carbonated drink products,” said Carsten Ullrich, one of the scientists involved in this study. “The quasiparticles are like those bubbles, and we found they can freely move around at remarkably fast speeds.” This discovery could help the development of a new generation of electronics that are faster, smarter, and more energy-efficient.

(Funded by the U.S. Department of Defense and the National Institutes of Health)
Scientists from The Ohio State University have combined strategies to deliver energy-disrupting gene therapy against cancer by using nanoparticles. Experiments showed the targeted therapy is effective at shrinking glioblastoma brain tumors and aggressive breast cancer tumors in mice. The approach consists of breaking up structures inside these cellular energy centers, called mitochondria, with a technique that induces light-activated electrical currents inside the cells. “Previous attempts to use a pharmaceutical reagent against mitochondria targeted specific pathways of activity in cancer cells,” said Lufang Zhou, one of the scientists involved in this study. “Our approach targets mitochondria directly, using external genes to activate a process that kills cells.”