(Funded by the National Institutes of Health)
Most cancers occur when there is an imbalance of cellular growth and inhibition, causing cells to grow rapidly and form tumors in the body. In the case of prostate cancer, no therapies exist to simultaneously correct tumor growth and restore tumor suppression. To restore this balance, researchers from Brigham and Women’s Hospital, which is part of Harvard Medical School, have used lipid nanoparticles to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) to human prostate cancer cells. This approach was successful in preclinical models, holding promise for suppressing tumor growth in patients.

(Funded by the U.S. Department of Energy)
Researchers from the U.S. Department of Energy’s Argonne National Laboratory and the University of Cambridge have unveiled the existence of an intriguing link between ferroelectric domain walls and electron interactions in a type of van der Waals 2D material. A domain wall is a boundary or interface separating regions inside a material that exhibit different orientations of ferroelectric polarization. The link discovered by the researchers gives rise to a new type of superconductivity that is unique to these 2D materials. “We showed that places like domain walls, typically associated with irregularities and potentially harmful for things like superconductivity, can indeed be helpful for superconductivity,” said Gaurav Chaudhary and Ivar Martin, the two authors of this study.

(Funded by the U.S. Department of Energy)
Researchers from the U.S. Department of Energy’s SLAC National Accelerator Laboratory, Stanford University, and the University of California, Davis, have developed a new software tool that can provide more quantitative details about the structure of the active sites in single atom catalysts in much less time, compared to current methods. Normally, a catalyst uses an inert support to stabilize nanometer-sized clusters of metal atoms, or metal nanoparticles. To maximize the use of each metal atom, researchers also use single atom catalysts, where individual metal atoms are dispersed onto the support. In reality, catalysts usually have both single atoms and nanoparticles, and the new software tool determines the fractions of these two forms.

(Funded by the U.S. National Science Foundation)
Researchers from Carnegie Mellon University have found a way to control the size and structure of active colloids while yielding more than 100 times the amount created by earlier fabrication methods. The team’s active colloids are linked together using DNA nanostructures – an innovation that makes them flexible, agile, and responsive to signals in their environment. Typically, DNA nanotechnology can only be studied using expensive equipment. In this case, because the DNA is attached to the colloid particles, researchers can observe any nanoscale phenomenon – such as the DNA structures changing shape – in real time by observing changes in the colloid’s movement under a microscope.

(Funded by the U.S. National Science Foundation)
Researchers from Stanford University; the IBM T.J. Watson Research Center in Yorktown Heights, NY; the Korea Electronics Technology Institute in Seongnam-si, South Korea; and Ajou University in Suwon, South Korea, have shown that niobium phosphide can conduct electricity better than copper in films that are only a few atoms thick. Many researchers have been working to find better conductors for nanoscale electronics, but so far the best candidates have had extremely precise crystalline structures, which need to be formed at very high temperatures. The niobium phosphide films made in this study are the first examples of non-crystalline materials that become better conductors as they get thinner, and they can be created at lower temperatures.