(Funded by the National Institutes of Health)
Researchers from the California NanoSystems Institute (CNSI) at the University of California, Los Angeles, have developed a patented technology that can inhibit and prevent the growth of pancreatic cancer in the liver. The technology’s goal is to reprogram the liver’s immune defense to attack pancreatic cancer. Key to this technology are liver-targeting nanoparticles that deliver two key components: an mRNA vaccine targeting an immune-activating marker commonly found in pancreatic cancer, and a small molecule that boosts the immune response. “This technology could potentially change the course of metastatic pancreatic cancer, as well as preventing spread to the liver in newly diagnosed patients without metastases,” said André Nel, one of the scientists involved in this study.

(Funded by the U.S. Department of Defense and the U.S. Department of Energy)
Researchers from the Department of Energy’s (DOE) Lawrence Berkeley National Laboratory (Berkeley Lab); the University of California, Berkeley; and Northwestern University have developed a way to engineer pseudo-bonds in materials. Instead of forming chemical bonds – which is what makes epoxies and other composites tough – the chains of molecules entangle in a way that is fully reversible. The researchers attached polystyrene chains to 100-nanometers-diameter silica particles to create “hairy particles.” These hairy particles self-assembled into a crystal-like structure, and the space available to each polystyrene chain depended on its position in the structure. While some chains became rigid under confinement, others ultimately disentangled and stretched. The result was a strong, tough, thin-film material, held firmly together by pseudo bonds of tangled polystyrene chains. The research was conducted, in part, at the Molecular Foundry, a DOE Office of Science user facility at Berkeley Lab.

(Funded by the U.S. Department of Defense and the U.S. Department of Energy)
Scientists from the U.S. Department of Energy’s Berkeley National Laboratory; the University of California, Berkeley; and Adamas Nanotechnologies Inc. in Raleigh, NC, have encased nanodiamonds – diamonds that are less than 100 nanometers in size – in tiny moving droplets of water to improve quantum sensing, a technology that uses quantum mechanics to measure physical quantities with high precision. As the droplets flowed past a laser and were hit by microwaves, the nanodiamonds gave off light. The amount of light in the presence of a microwave field was related to the materials around the nanodiamond, letting scientists determine whether a chemical of interest was nearby.

(Funded by the U.S. Department of Defense and the U.S. National Science Foundation)
Researchers from Cornell University and the Army Research Laboratory have devised a new method for designing metals and alloys that can withstand extreme impacts. When a metallic material is struck at an extremely high speed, it immediately ruptures and fails. The reason for that failure is embrittlement – the material loses its ability to bend without breaking – when deformed rapidly. The researchers created a nanocrystalline alloy made of copper and tantalum in which dislocations could barely move more than a few nanometers before they were stopped in their tracks, effectively suppressing embrittlement. Dislocations are tiny defects that move through a crystal. During rapid, extreme strains, the dislocations accelerate and interact with lattice vibrations, which create substantial resistance that leads to embrittlement.

(Funded by the U.S. Department of Energy and the U.S. National Science Foundation)
Researchers from the U.S. Department of Energy’s (DOE) Oak Ridge National Laboratory (ORNL), Purdue University, and the University of Illinois Urbana−Champaign have used a nanoscale quantum sensor to measure spin fluctuations near a phase transition in a magnetic thin film. Thin films with magnetic properties at room temperature are essential for data storage, sensors and electronic devices because their magnetic properties can be precisely controlled and manipulated. The researchers used a specialized instrument called a scanning nitrogen-vacancy center microscope at the Center for Nanophase Materials Sciences, a DOE Office of Science user facility at ORNL. A nitrogen-vacancy center is an atomic-scale defect in diamond in which a nitrogen atom takes the place of a carbon atom, and a neighboring carbon atom is missing, creating a special configuration of quantum spin states.