(Funded by the National Science Foundation and the U.S. Department of Defense)
Researchers at the Massachusetts Institute of Technology have developed a new filtration material that might provide a nature-based solution to water contaminated by “forever chemicals,” or per- and poly-fluoroalkyl substances (PFAS). The filtration material, based on natural silk and cellulose, can remove a variety of these persistent chemicals, as well as heavy metals. The researchers devised a way of processing silk proteins into uniform nanoscale crystals, or “nanofibrils.” Then, they integrated cellulose into the silk-based fibrils, which formed a thin membrane that was highly effective at removing PFAS in lab tests.

(Funded by the National Institutes of Health and the National Science Foundation)
A research team from Brown University has developed a new method for transferring the ions that mass spectrometers analyze, dramatically reducing sample loss so that nearly all of it remains intact. “Basically, it’s a process where you’re really spraying your sample all over the place to produce these ions and only get a tiny portion of them into the mass spectrometer’s vacuum for analysis,” said Nicholas Drachman, a physics Ph.D. student who led the work. “Our approach skips all of that.” The key is a nanotube the researchers developed that has an opening about 30 nanometers across. For comparison, the conventional needle used in electrospray has an opening of about 20 micrometers across. The new nanotube also has the unique ability to transfer ions that are dissolved in water directly into the vacuum of a mass spectrometer, rather than producing a spray of droplets that must be dried out to access the ions.

(Funded by the National Science Foundation and the National Institutes of Health)
Researchers at the University of Pennsylvania have found that small extracellular vesicles are secreted by tumor cells and act as a “forcefield,” blocking nanoparticle-based therapies aimed at targeting cancers. “A lot like the Death Star with its surrounding fleet of fighter ships and protective shields, solid tumors can use features like immune cells and vasculature to exert force, acting as a physical barrier to rebel forces (nanoparticles) coming in to deliver the payload that destroys it,” said Michael Mitchell, one of the researchers involved in this study.

(Funded by the U.S. Department of Defense, the National Science Foundation and the U.S. Department of Energy)
In the 1970s, scientists began exploring ways to extend electronic frequency mixing into the terahertz range using diodes. While these early efforts showed promise, progress stalled for decades. Recently, however, advances in nanotechnology have reignited this area of research. Now, researchers at the Massachusetts Institute of Technology have developed an electronic frequency mixer for signal detection that operates beyond 0.350 petahertz using tiny nanoantennae. These nanoantennae can mix different frequencies of light, enabling analysis of signals oscillating orders of magnitude faster than the fastest signal accessible to conventional electronics.

(Funded by the National Institutes of Health, the National Science Foundation and the U.S. Department of Defense)
Scientists from the Massachusetts Institute of Technology, Harvard Medical School, Carnegie Mellon University, Georgia Institute of Technology, and the University of California, Riverside, have developed polymeric nanocarriers that can cross plant cell walls, delivering functional proteins directly into the cells with unprecedented efficiency. These nanocarriers are engineered with a high aspect ratio, meaning they are long and thin, which is essential for their ability to cross the plant cell wall. One of the critical findings of the study is that the efficiency of protein delivery highly depends on the size and charge of the nanocarriers: Nanocarriers with a width greater than 14 nanometers or with insufficient positive charge were less effective at penetrating the plant cell wall and delivering their protein cargo.