(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers at the University of Pennsylvania have shown that lipid nanoparticles can mediate more than 100-fold greater mRNA delivery to the placenta of pregnant mice with pre-eclampsia than a lipid nanoparticle formulation approved by the U.S. Food and Drug Administration. These lipid nanoparticles can decrease high blood pressure and increase vasodilation in these pre-eclamptic pregnant mice.

(Funded by the U.S. National Science Foundation)
Researchers from Florida State University; the National High Magnetic Field Laboratory in Tallahassee, FL; and the Universitat de València in Spain have unlocked a new method for producing one class of 2D material and for supercharging its magnetic properties. Experimenting on a metallic magnet made from the elements iron, germanium and tellurium, the research team made two breakthroughs: a collection method that yielded 1,000 times more material than typical practices, and the ability to change the material’s magnetic properties through a chemical treatment. “We’re moving toward developing more efficient electronic devices that consume less power, are lighter, faster and more responsive,” said Michael Shatruk, the scientist who led this study. “2D materials are a big part of this equation, but there’s still a lot of work to be done to make them viable. Our research is part of that effort.”

(Funded by the U.S. National Science Foundation and the National Institutes of Health)
Researchers at the University of Kentucky and the New York Blood Center in New York City have discovered that combining magnetic nanoparticles with ascorbic acid destroyed breast cancer cells, but only if the nanoparticles were added and went inside the cells first before the ascorbic acid was added. “This discovery underscores the significance of coordinating nanoparticles and ascorbic acid in cancer treatment,” said Sheng Tong, the scientist who led this study. The researchers also engineered a specific type of immune cell, called macrophages, to carry the nanoparticles to the tumor site. When loaded with magnetic nanoparticles, the macrophages can be guided to the tumor using an external magnetic field.

(Funded by the U.S. Department of Energy and the U.S. National Science Foundation)
Materials that conduct electricity well, like metals, also tend to conduct heat. But researchers at Drexel University, Villanova University, Temple University, Bryn Mawr College, Rice University, and Université catholique de Louvain in Belgium have discovered that MXenes, a type of material known for its excellent electrical conductivity, actually have very low thermal conductivity. This discovery challenges the usual link between electrical and heat conduction and could lead to new developments in building materials, performance apparel, and energy storage solutions. “Thermal insulation of this magnitude … would simply have been unimaginable until now,” said Yury Gogotsi, one of the scientists involved in this research. “This could change the way we insulate buildings and industrial equipment, and make thermal clothing, just to name a few exciting possibilities.”

(Funded by the U.S. Department of Energy, the U.S. National Science Foundation, and the National Institutes of Health)
Researchers at Southern Methodist University, the University of Texas at Arlington, the U.S. Department of Energy’s Brookhaven National Laboratory, and the Korea Institute of Science and Technology in Seoul have discovered a way to enhance the sensitivity of nanopores for early detection of diseases. They integrated octahedral DNA origami structures with solid-state nanopores to significantly improve the detection of proteins, especially those that are present in low concentrations. Nanopores are tiny holes that can detect individual molecules as they pass through. The researchers determined that combining the precision of DNA origami with the robustness of solid-state nanopores could create a “hybrid nanopore” system, enabling more precise analysis.