(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers from the University of Rhode Island and Brown University have shown that carbon nanotubes could be combined with machine learning to detect subtle differences between closely related immune cells. The researchers used an in vitro experiment that involved placing live cells into a culture dish, adding carbon nanotubes, and then using a specialized microscope with an infrared camera to observe the emitted light from each cell. The camera generated millions of data points, each of which reflected cellular activity. Healthy cells emitted one type of light, while potentially unhealthy or changing cells emitted different light patterns.

(Funded by the National Institutes of Health)
Researchers from the California NanoSystems Institute (CNSI) at the University of California, Los Angeles, have developed a patented technology that can inhibit and prevent the growth of pancreatic cancer in the liver. The technology’s goal is to reprogram the liver’s immune defense to attack pancreatic cancer. Key to this technology are liver-targeting nanoparticles that deliver two key components: an mRNA vaccine targeting an immune-activating marker commonly found in pancreatic cancer, and a small molecule that boosts the immune response. “This technology could potentially change the course of metastatic pancreatic cancer, as well as preventing spread to the liver in newly diagnosed patients without metastases,” said André Nel, one of the scientists involved in this study.

(Funded by the National Institutes of Health)
Researchers from the University of Illinois Urbana-Champaign have developed organic-material-based nanozymes – synthetic nanomaterials that have enzyme-like catalytic properties – that are non-toxic, environmentally friendly, and cost effective. To create these nanozymes, the researchers used a novel particle synthesis technique that brought each nanozyme’s size down to less than 100 nanometers. In one study, the researchers showed that these nanozymes, combined with a colorimetric sensing platform, could detect the presence of histamine in spinach and eggplant. In another study, the nanozymes were used to detect the presence of glyphosate, a common agricultural herbicide, in plants. “We were able to show that our system doesn’t just work in the lab, it has the potential to be utilized for real-world applications as a cost-effective molecule sensing system for food and agriculture,” said Dong Hoon Lee, lead author of the study.

(Funded by the National Institutes of Health)
Researchers from Baylor College of Medicine and Pennsylvania State University have discovered that Zika virus builds a series of tiny tubes, called tunneling nanotubes, that facilitate the transfer of viral particles to neighboring uninfected cells. The tiny conduits also provide a means to transport RNA, proteins and mitochondria, a cell’s main source of energy, from infected to neighboring cells. “Altogether, we show that Zika virus uses a tunneling strategy to covertly spread the infection in the placenta while hijacking mitochondria to augment its propagation and survival,” said Indira Mysorekar, one of the scientists involved in this study. “We propose that this strategy also protects the virus from the immune response.”

(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers from the University of Pennsylvania, Rutgers University, and East China University of Science and Technology in Shanghai have shown that a combination of messenger RNA (mRNA) and a new lipid nanoparticle could help heal damaged lungs. The researchers matched up mRNA with just one unique lipid nanoparticle – ionizable amphiphilic Janus dendrimers – which are organ-specific. When it reaches the lung, the mRNA instructs the immune system to create transforming growth factor beta, a signaling molecule that is used to repair tissue. “This research marks the birth of a new mRNA delivery platform,” said 2023 Nobel laureate Drew Weissman, a co-author of the study. “While using other lipid nanoparticles works great to prevent infectious diseases, … this new platform does not have to be stored at such extremely cold temperatures and is even easier to produce.”