(Funded by the National Institutes of Health)
Scientists from The Wistar Institute, the University of Pennsylvania, the Icahn School of Medicine at Mount Sinai, Saint Joseph’s University (Philadelphia, PA), and Inovio Pharmaceuticals (Plymouth Meeting, PA) have described a next-generation vaccination technology that combines plasmid DNA with a lipid nanoparticle delivery system. The team showed that these DNA lipid nanoparticles demonstrate a unique way of priming the immune system compared to mRNA and protein-in-adjuvant formulations and that these DNA lipid nanoparticles induced robust antibody and T-cell responses after a single dose. Importantly, these responses were durable, with memory responses in small animals persisting beyond a year after immunization.

(Funded by the National Institutes of Health)
Researchers from Oregon State University, Oregon Health & Science University, and international collaborators have developed magnetic nanoparticles in the shape of a cube sandwiched between two pyramids for the treatment of ovarian cancer. Made of iron oxide and doped with cobalt, the nanoparticles show exceptional heating efficiency when exposed to an alternating magnetic field. When the particles accumulate in cancerous tissue after intravenous injection, they are able to quickly rise to temperatures that weaken or destroy cancer cells. A cancer-targeting peptide helps the nanoparticles accumulate in the tumor, and because the nanoparticles’ heating efficiency is strong, the necessary concentration of nanoparticles can be achieved without a high dosage, limiting toxicity and side effects.

(Funded by the U.S. Department of Energy and the National Institutes of Health)
Researchers at Cornell University have, for the first time, identified what happens when bacteria receive electrons from quantum dots. Using fluorescence lifetime imaging microscopy with two-photon excitation on a quantum dot and bacteria, the researchers identified a distinct halo surrounding the bacteria, which suggested the charge transfer was receiving some peripheral assistance. It turned out that an electron could either move directly from the quantum dot to the bacterium or be transferred from the bacterium via shuttle molecules. Photosynthetic biohybrids of this sort could potentially convert carbon dioxide into value-added chemical products, such as bioplastics and biofuels, and control other microbial processes.

(Funded by the National Institutes of Health)
Scientists from The Johns Hopkins University, the Mayo Clinic, and Tufts University have developed a potential new way to treat a variety of rare genetic diseases marked by too low levels of specific cellular proteins. To boost those proteins, the scientists created a genetic “tail” that attaches to messenger RNA (mRNA) molecules that churn out the proteins. To deliver these genetic tails, also called “mRNA boosters,” the scientists encased them in nanoparticles covered in lipids. The nanoparticles are naturally absorbed by cells through their fatty outer membranes. After the scientists administered the mRNA boosters to laboratory mice, each group of mice had 1.5 to two times more of the proteins specific to the mRNA boosters than control mice that did not receive the boosters.

(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers from Carnegie Mellon University and the University of Southern California have devised a method to create large amounts of a material that can be used to make two-dimensional (2D) semiconductors with record high performance. That material, tellurium, has a fast conducting speed and is stable in the air, so it does not easily degrade. The researchers used 2D tellurium to create an ultralight-weight photodetector – a device that can detect light – which is highly tunable, allowing its parameters to be changed so it can be used in a variety of applications, a property that is not true of other photodetectors.