(Funded by the U.S. Department of Energy and the National Institutes of Health)
Researchers at Cornell University have, for the first time, identified what happens when bacteria receive electrons from quantum dots. Using fluorescence lifetime imaging microscopy with two-photon excitation on a quantum dot and bacteria, the researchers identified a distinct halo surrounding the bacteria, which suggested the charge transfer was receiving some peripheral assistance. It turned out that an electron could either move directly from the quantum dot to the bacterium or be transferred from the bacterium via shuttle molecules. Photosynthetic biohybrids of this sort could potentially convert carbon dioxide into value-added chemical products, such as bioplastics and biofuels, and control other microbial processes.

(Funded by the National Institutes of Health)
Scientists from The Johns Hopkins University, the Mayo Clinic, and Tufts University have developed a potential new way to treat a variety of rare genetic diseases marked by too low levels of specific cellular proteins. To boost those proteins, the scientists created a genetic “tail” that attaches to messenger RNA (mRNA) molecules that churn out the proteins. To deliver these genetic tails, also called “mRNA boosters,” the scientists encased them in nanoparticles covered in lipids. The nanoparticles are naturally absorbed by cells through their fatty outer membranes. After the scientists administered the mRNA boosters to laboratory mice, each group of mice had 1.5 to two times more of the proteins specific to the mRNA boosters than control mice that did not receive the boosters.

(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers from Carnegie Mellon University and the University of Southern California have devised a method to create large amounts of a material that can be used to make two-dimensional (2D) semiconductors with record high performance. That material, tellurium, has a fast conducting speed and is stable in the air, so it does not easily degrade. The researchers used 2D tellurium to create an ultralight-weight photodetector – a device that can detect light – which is highly tunable, allowing its parameters to be changed so it can be used in a variety of applications, a property that is not true of other photodetectors.

(Funded by the National Institutes of Health and the U.S. National Science Foundation)
Researchers from the University of Rhode Island and Brown University have shown that carbon nanotubes could be combined with machine learning to detect subtle differences between closely related immune cells. The researchers used an in vitro experiment that involved placing live cells into a culture dish, adding carbon nanotubes, and then using a specialized microscope with an infrared camera to observe the emitted light from each cell. The camera generated millions of data points, each of which reflected cellular activity. Healthy cells emitted one type of light, while potentially unhealthy or changing cells emitted different light patterns.

(Funded by the National Institutes of Health)
Researchers from the California NanoSystems Institute (CNSI) at the University of California, Los Angeles, have developed a patented technology that can inhibit and prevent the growth of pancreatic cancer in the liver. The technology’s goal is to reprogram the liver’s immune defense to attack pancreatic cancer. Key to this technology are liver-targeting nanoparticles that deliver two key components: an mRNA vaccine targeting an immune-activating marker commonly found in pancreatic cancer, and a small molecule that boosts the immune response. “This technology could potentially change the course of metastatic pancreatic cancer, as well as preventing spread to the liver in newly diagnosed patients without metastases,” said André Nel, one of the scientists involved in this study.