(Funded by the National Institutes of Health and the National Institute of Standards and Technology)
Researchers from Johns Hopkins University and the National Institute of Standards and Technology have developed a new blood test that diagnoses heart attacks in minutes rather than hours. The heart of the invention is a tiny chip with a groundbreaking nanostructured surface on which blood is tested. The chip’s “metasurface” enhances electric and magnetic signals during Raman spectroscopy analysis, making heart attack biomarkers visible in seconds. The tool is sensitive enough to flag heart attack biomarkers that might not be detected with current tests. “We’re talking about speed, we’re talking about accuracy, and we’re talking of the ability to perform measurements outside of a hospital,” said Ishan Barman, one of the scientists involved in this study.

(Funded by the National Institutes of Health)
Researchers at the Massachusetts Institute of Technology and Friedrich-Alexander University of Erlangen–Nuremberg in Germany have developed novel magnetic nanodiscs that could provide a less invasive way of stimulating parts of the brain, paving the way for stimulation therapies without implants or genetic modification. Deep brain stimulation (DBS) is a common clinical procedure that uses electrodes implanted in the target brain regions to treat symptoms of neurological and psychiatric conditions. Despite its efficacy, the surgical difficulty and clinical complications associated with DBS limit the number of cases where such an invasive procedure is warranted. The new nanodiscs could provide a more benign way of achieving the same results.

(Funded by the National Science Foundation, the U.S. Department of Energy, and the National Institutes of Health)
Using peptides and a snippet of the large molecules in plastics, scientists at Northwestern University have developed materials made of tiny, flexible nano-sized ribbons that can be charged just like a battery to store energy or record digital information. Highly energy efficient, biocompatible and made from sustainable materials, the systems could give rise to new types of ultralight electronic devices while reducing the environmental impact of electronic manufacturing and disposal. “This is a wholly new concept in materials science and soft materials research,” said Samuel I. Stupp, the scientist who led the study. “We imagine a future where you could wear a shirt with air conditioning built into it or rely on soft bioactive implants that feel like tissues and are activated wirelessly to improve heart or brain function.”

(Funded by the National Institutes of Health)
Researchers from the University of California, Los Angeles, have unveiled a new platform that combines a flexible material called graphene oxide with antibodies to closely mimic the natural interactions between immune cells. The investigators found that this platform shows a high capacity for stimulating T cells to reproduce, while preserving their versatility and potency. The advance could make CAR-T cell therapy more effective and accessible. In this type of therapy, patients’ own immune cells are collected, genetically engineered so that they specifically target cancer cells, and then returned to the body. The new technology enhanced the efficiency of engineering immune cells, leading to a five-fold increase in CAR-T cell production, compared to the standard process.

(Funded by the National Science Foundation, the U.S. Department of Energy, and the National Institutes of Health)
By fusing together a pair of contorted molecular structures, researchers from Cornell University, Rice University, the University of Chicago, and Columbia University have created a porous #crystal that can uptake #lithium-ion #electrolytes and transport them smoothly via one-dimensional #nanochannels – a design that could lead to safer solid-state #LithiumIonBatteries. The researchers devised a method of fusing together two eccentric molecular structures that have complementary shapes: #macrocycles and #MolecularCages. “Both macrocycles and molecular cages have intrinsic pores where ions can sit and pass through,” said Yuzhe Wang, one of the scientists involved in this study. “By using them as the building blocks for porous crystals, the crystal would have large spaces to store ions and interconnected channels for ions to transport.”