(Funded by the U.S. Department of Defense and the National Institutes of Health)
Scientists from the City University of New York, the Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine have developed a groundbreaking approach using nanoparticles that are primarily composed of a drug and a thin peptide coating which improves solubility, enhances stability in the body, and optimizes delivery to targeted areas. In leukemia models, the nanoparticles were more effective at shrinking tumors compared to the drug alone. “Using specially designed peptides, we can build nanomedicines that make existing drugs more effective and less toxic and even enable the development of drugs that might not be able to work without these nanoparticles,” said Daniel Heller, one of the scientists involved in this study.

(Funded by the U.S. National Science Foundation, the U.S. Department of Defense, and the National Institutes of Health)
Researchers from Northwestern University, Duke University, and Cornell University have developed the first two-dimensional mechanically interlocked material. Looking like the interlocking links in chainmail, the nanoscale material exhibits exceptional flexibility and strength. With further work, this material holds promise for use in high-performance, light-weight body armor and other uses that demand lightweight, flexible, and tough materials. “We made a completely new polymer structure,” said William Dichtel, the study’s corresponding author. “It’s similar to chainmail in that it cannot easily rip because each of the mechanical bonds has a bit of freedom to slide around. If you pull it, it can dissipate the applied force in multiple directions. And if you want to rip it apart, you would have to break it in many, many different places.”

(Funded by the U.S. Department of Defense, the U.S. Department of Energy, and the U.S. National Science Foundation)
Researchers from the Massachusetts Institute of Technology, Purdue University, Stanford University, Rice University, and the U.S. Department of Energy’s Lawrence Berkeley National Laboratory, Argonne National Laboratory, and Oak Ridge National Laboratory have described how a type of quasiparticle, called a polaron, behaves in tellurene, a nanomaterial made up of tiny chains of tellurium atoms. A polaron forms when charge-carrying particles such as electrons interact with vibrations in the atomic or molecular lattice of a material. The researchers had hypothesized that as tellurene transitions from bulk to nanometer thickness, polarons change from large, spread-out electron-vibration interactions to smaller, localized interactions. Computations and experimental measurements backed up this scenario.

(Funded by the U.S. Department of Energy and the U.S. Department of Defense)
Researchers from Columbia University, the University of Chicago, the University of Vienna in Austria, Politecnico di Milano in Italy, and Universita Degli Studi Dell’ Aquila in Italy have created a device that can generate photon pairs more efficiently than previous methods while being less prone to error. To create the device, the researchers used thin crystals of a van der Waals semiconducting transition metal called molybdenum disulfide. Then, they layered six of these crystal pieces into a stack, with each piece rotated 180 degrees relative to the crystal slabs above and below. As light travels through this stack, a phenomenon called quasi-phase-matching manipulates properties of the light, enabling the creation of paired photons. “We believe this breakthrough will establish van der Waals materials as the core of next-generation nonlinear and quantum photonic architectures,” said James Schuck, one of the scientists involved in this study.

(Funded by the U.S. Department of Energy, the U.S. Department of Defense, and the U.S. National Science Foundation)
Scientists from Oregon State University; the Molecular Foundry at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory; Columbia University; and the Autonomous University of Madrid, Spain, have discovered luminescent nanocrystals that can be quickly toggled from light to dark and back again. “Normally, luminescent materials give off light when they are excited by a laser and remain dark when they are not,” said Artiom Skripka, one of the scientists involved in this study. “In contrast, we were surprised to find that our nanocrystals live parallel lives. Under certain conditions, they show a peculiar behavior: They can be either bright or dark under exactly the same laser excitation wavelength and power.”