(Funded by the National Institutes of Health)
A nanoparticle vaccine designed to fight cancers induced by human papillomavirus (HPV) eradicated tumors in an animal model of late-stage metastatic disease. The findings could ultimately lead to a new type of vaccine that would be used to treat a variety of cancers. To develop a therapeutic vaccine against HPV-related cancers, researchers combined a polymer and a small-molecule drug that both activate stimulator of interferon genes (STING) – a protein that triggers immune activity – with a protein antigen called E7 derived from HPV. Together, these components formed nanoparticles about 25-30 nanometers in diameter (for comparison, 1 million nanometers equal 1 millimeter).
https://www.utsouthwestern.edu/newsroom/articles/year-2025/nov-nanovaccine-hpv-related-cancers.html
