Biomedical

Engineers at the University of Pennsylvania have modified lipid nanoparticles to not only cross the blood-brain barrier but also to target specific types of cells, including neurons. The researchers showed how short strings of amino acids can serve as precise targeting molecules, enabling the lipid nanoparticles to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer's and Parkinson's.

Scientists from The Ohio State University have combined strategies to deliver energy-disrupting gene therapy against cancer by using nanoparticles. Experiments showed the targeted therapy is effective at shrinking glioblastoma brain tumors and aggressive breast cancer tumors in mice. The approach consists of breaking up structures inside these cellular energy centers, called mitochondria, with a technique that induces light-activated electrical currents inside the cells.

Nanoparticles have transformed how mRNA vaccines and therapeutics are delivered by allowing them to travel safely through the body, reach target cells and release their contents efficiently. At the heart of these nanoparticles are ionizable lipids, special molecules that can switch between charged and neutral states depending on their surroundings. Now, researchers at the University of Pennsylvania have used an iterative process to find the ideal structure for the ionizable lipid.

Rice University scientists have developed halide perovskite nanocrystals that have shown potential as antimicrobial agents that are stable, effective, and easy to produce. The scientists developed a method that coated the halide perovskite nanocrystals in two layers of silicon dioxide. Next, they tested the antimicrobial properties and durability of the double-coated halide perovskite nanocrystals and showed that under relatively low levels of visible light, the halide perovskite nanocrystals destroyed more than 90% of E.

Researchers at Rice University have developed an innovative imaging platform that promises to improve our understanding of cellular structures at the nanoscale. This platform offers significant advancements in super-resolution microscopy, enabling fast and precise three-dimensional (3D) imaging of multiple cellular structures.

Researchers from the University of North Carolina Charlotte and the U.S. Department of Energy’s Brookhaven National Laboratory have developed an innovative computational framework for modeling multifunctional RNA nucleic acid nanoparticles. By integrating small and wide-angle x-ray scattering data with data-driven molecular dynamics simulations, the researchers developed a methodology for studying multistranded RNA nucleic acid nanoparticles in their solution-state environments.

Researchers at the University of California San Diego have developed a platform for studying how  nanoscale growing surfaces can impact cellular behavior. While previous studies have shown how surface structures can change cellular shape, little is known about their specific effects on cell metabolism. The research team found that cells grown on engineered nanopillar surfaces show dramatically different metabolic profiles than cells not grown on such surfaces.

Researchers from Carnegie Mellon University and the Indian Institute of Technology Bombay in Mumbai, India, have linked the immune response caused by lipid nanoparticles to their lipid chemistry. They found that some lipid structures bind strongly to receptors and others bind weakly. The strong interactions trigger the receptor and ultimately the immune response. The findings will help engineers tailor immune responses when designing lipid nanoparticles for drug delivery.

Researchers from the University of Chicago; the University of California, Berkeley; Northwestern University; the University of Colorado Boulder; and  the U.S. Department of Energy’s Argonne National Laboratory have developed a new technique for growing quantum dots – nanocrystals used in lasers, quantum light-emitting diode (QLED) televisions, and solar cells. The researchers replaced organic solvents typically used to create quantum dots with molten salt – literally superheated sodium chloride of the type sprinkled on baked potatoes.

Researchers at the Massachusetts Institute of Technology have designed tiny particles that can be implanted at a tumor site, where they deliver two types of therapy: heat and chemotherapy. In a study of mice, the researchers showed that this therapy completely eliminated tumors in most of the animals and significantly prolonged their survival. To create a microparticle that could deliver both of these treatments, the researchers combined an inorganic material called molybdenum disulfide nanosheets with one of two drugs: doxorubicin or violacein.