Researchers from Carnegie Mellon University and the Indian Institute of Technology Bombay in Mumbai, India, have linked the immune response caused by lipid nanoparticles to their lipid chemistry. They found that some lipid structures bind strongly to receptors and others bind weakly. The strong interactions trigger the receptor and ultimately the immune response. The findings will help engineers tailor immune responses when designing lipid nanoparticles for drug delivery. "For vaccines, we might want something that's more immunogenic, so that the vaccine responds better,” said Namit Chaudhary, one of the scientists involved in this study. “But if we are delivering something to the brain or the liver, for example, we might not want to evoke substantial immune responses that might cause toxicity."
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