Nanoparticles can turn off genes in bone marrow cells

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Funding Agency
(Funded in part by the National Institutes of Health)

Using specialized nanoparticles, engineers at MIT have developed a way to turn off specific genes in cells of the bone marrow, which play an important role in producing blood cells. This type of genetic therapy, known as RNA interference, is usually difficult to target to organs other than the liver, where nanoparticles tend to accumulate. The MIT researchers were able to modify their particles in such a way that they would accumulate in the cells found in the bone marrow. In a study of mice, the researchers showed that they could use this approach to improve recovery after a heart attack by inhibiting the release of bone marrow blood cells that promote inflammation and contribute to heart disease.